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Asked by anon-199714 to Sylvia, Sumit, Martin, Kate, Bryony, Aryanne on 12 Mar 2019.
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Sumit Konar answered on 12 Mar 2019:
X-ray crystallography (discovered more than 100 years ago). X-rays can hit atomic planes and diffract as spots; it looks like stars in the sky. From these spots we can see how atoms are packed.
Raman spectroscopy: It tells us how bonds vibrate; discovered by an Indian scientist in the last century.
High pressure method: introduced almost 65 years ago by Bridgman (American scientist). We can generate thousands and millions times high pressure the atmospheric pressure. This is how we make synthetic diamonds from graphite.
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Martin McCoustra answered on 12 Mar 2019:
There are probably two things… First that simple dipolar molecules don’t behave as we might expect… and that water ice supports a mechanism for transporting energy relatively long distances on the molecular scale.
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Kate McGonagle answered on 13 Mar 2019:
Oh this is a hard question because there are SO many discoveries that have led to the point we are at now in drug discovery. First the discovery of atoms, elements and the building of the periodic table. Then the constant discovery of new ways to make bonds, informing us how to build molecules up. For my current work, also the discovery of Chagas disease and the parasite which causes it being T.Cruzi!
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Sylvia Soldatou answered on 13 Mar 2019:
There are so many discovereis that have lead up tot my current work. I agree with what Kate mentioned about the fundamental discoveries and being more specific for my resercah field, I would say that the development of Nuclear Magentic Resonance (NMR) spectroscopy has made it possible for us to solve the structures of teh new molecules we isolate from nature.
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